Functional Roles of Notable microRNAs

Below are some of the most widely studied miRNAs and their recognized molecular functions within cellular systems:

▪ miR-21

• Plays a role in modulating cell growth and maintaining cellular equilibrium.
• Influences transcriptional responses related to signaling pathways and cellular repair.

▪ Let-7 Family

• Participates in cell differentiation and developmental timing.
• Commonly involved in systems that control growth and identity of cells.

▪ miR-155

• Contributes to the fine-tuning of genetic feedback mechanisms during environmental stress.
• Associated with modulation of intracellular signaling cascades.

▪ miR-16

• Involved in managing mRNA stability and turnover.
• Often linked with homeostasis of proliferation-related transcripts.

▪ miR-34a

• Influences cell cycle checkpoints and contributes to molecular feedback loops.
• Functions in pathways regulating structural protein expression and coordination.

▪ miR-210

• Responsive to environmental oxygen variations.
• Supports adaptation and metabolic adjustments under low-energy conditions.

▪ miR-122

• Highly abundant in certain cellular environments like hepatic tissue.
• Involved in managing lipid-related gene expression.